The achievement of a proper silicone layer formation on glass primary packaging is crucial in developing robust parenteral/device/combination products that are stable during their shelf life and delivery to the patient. This webinar will focus on optimizing the silicone spraying process on glass barrels by combining a mathematical modeling approach and experimental data. We will share our DOE approach to optimize the silicone spraying process, the mathematical model, and experimental results. We will also discuss outcomes on silicon layer stability. Finally, we will present an overview of analytical capabilities in terms of silicon layer characterization and performance, focusing on customized case studies.